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WyattQELS Dynamic Light Scattering Module
The WyattQELS® embedded dynamic light scattering (DLS) module integrates into any Wyatt multi-angle light scattering (MALS) detector—the DAWN®, miniDAWN® or microDAWN®—in order to measure particle sizes online, in conjunction with standard size exclusion chromatography or the Eclipse® asymmetric-flow field-flow fractionation (AF4) system. This capability is utilized in the ASTRA® chromatography software to provide accurate macromolecular and nanoparticle size distributions.
Features
Integrates directly inside the MALS detector, using the MALS laser and flow cell, for simultaneous MALS and DLS measurements
Does not introduce additional band broadening or interdetector delay
Range of hydrodynamic radius Rh with flow: DAWN – 0.5 nm to 200 nm; miniDAWN – 0.5 nm to 50 nm; microDAWN – 0.5 nm to 30 nm
Range of hydrodynamic radius Rh without flow: 0.5 nm to 1000 nm in all MALS detectors.
Applications
Protein and polymer size and conformation
Accurate, high-resolution nanoparticle size and shape distributions
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