The GJE-100ML Jacketed Liposome Extruder

The Genizer Jacketed Liposome Extruder uses a nitrogen gas cylinder to force a drug, proteinor gene liposome suspension via a track-etched membrane with a predetermined pore size; generally, 5–10 passes are enough to create a sample with consistent liposome size. The Genizer Jacketed Liposome Extruders are intended to produce uniform unilamellar liposomes and Lipopolyplex with minimal dead volume.

Genizer GJE-100mL, Jacketed Liposome Extruder. Image Credit: Genizer LLC

Liposome particle with phospholipid molecules. Image credits: Genizer LLC

The operation procedure is easy and simple. Users can set the big pore support disc in the filter support base first, followed by the laser disc (smooth side up), one drain disc, then the liposome membrane (shiny side up).

A high-pressure nitrogen tubing comes as standard. This then needs to be added to the gas cylinder’s regulator to complete the GJE-100mL.

To generate the pressure, the user needs to simply load the thermal barrelwith the sample, then switch on the regulator. To obtain nano-scale particle sizes, the sample needs topassthrough the track-etched nanopore membrane.

Features

The capacity of the extruder barrel: 100 mL

Filter diameter: 25 mm

Spares: O-rings, collection silicone tubing

Material: 316L stainless steel, NBR or Viton

Cooling: jacketed thermo barrel

Additional features: Large pore support screen, laser micro pore disc, high pressure nitrogen tubing G5/8

Genizer Jacketed Liposome Extrusion System. Image Credit: Genizer LLC