PolyBLOCK High Pressure: A High Pressure, Bench Top, Automated Parallel Synthesis Platform

The platform’s ability to support high pressure reactor vessels enables high pressure reactions to be studied, whetherthat is screening or DoE campaigns further into process development. It also facilitates the exploration of pressure effects on chemistry of interest, increasing reaction understanding and facilitating scale-up operations.

Features and Options:

Temperature Control

Ambient to 250 ⁰C (without external cooling)

Options to decrease the range down to-40 ⁰C(circulator dependent)

Separate mantle around each reactor allows the temperature to be controlled individually, with arange/difference of over 50 °C between the reactors

Independent Stirring

Indirect agitation with magnetic stirrer bar as standard.

• Suspended mechanical agitation for efficient mixing on small-scale and non-viscous samples.

• Optional Overhead direct agitation for larger vessels.

  Intelligent Software Control and Analysis

  labCONSOL software control enables regular data logging, multi-step recipes, parameter control, and feedback loops. The software adds a responsive intelligence to the PolyBLOCK 4 system and still delivers an intuitive interface that needs only minimal training to run quickly.

  Safety Features

  Include automatic user-configurable reaction detection and shutdown procedures,to ensure user safety.

  Compact manifold for easy manual purge and pressurisation.

  Automatic hardware and software fail-safes are installed on every system.

  Condensing Options

  • Easy quick-connect solution for condensing and inerting in larger reactors. Seals allow condensers to be removed without cooling liquid spillage.

    Also available reflux and inerting block, with adapters for vials, tubes, and reactors.

    Reactor Options

    Vessel typesare available in Stainless Steel orHastelloy. Commonly volumes are 16 ml, 25ml, and 50 ml reactors, all stirred and with separate temperature control. Larger volumes, up to 500 ml are available.

    High Pressure and Vacuum Systems

    Each reactor can be independently pressurizedup to 200 bar.

    Individual reactors can be pressurized by Mass Flow Controllers (MFC's) for increased pressure control.

    Automated measuring of gas-uptake during reaction available for both MFC and non-MFC systems.

    Sampling Systemsthrough active pumps, manual dip tubes, automated level control, or multisampling units, like the ASU.

    Reagent Additionthrough fully automated liquidand gas feeds as well as volumetric syringe pumps. These solutions can be applied to both high and low-pressure systems.

    Control Optionsall relevant inputs can be logged, enabling automated monitoring and, where appropriate, feedback control of the reactor system.

    Sensor Options

    Temperature, pressure, pH, turbidity, conductivity.

    Integration of third-party probes is possible, such as in-situ FTIR, particle sizing probes and Raman probes.