Litesizer Series of Particle Size Analyzers

上海仪舶实验室自动化 25-01-23 12:56:43

Litesizer Series of Particle Size Analyzers

The Litesizer DLS series classifies nanoparticles and microparticles at the press of a button. These dynamic light scattering devices allow users to identify particles in dispersion as well as peptides or macromolecules in solution across a wide concentration range, reducing sample preparation time.

Litesizer DLS 100

Particle size measurements from the nanometer to the micrometer range

DLS backscatter detection ensures a broad concentration range

Automatic measurement modes

Continuous transmittance measurement

Litesizer DLS 500

Particle characterization from the nanometer to the micrometer range

Particle size measurements using dynamic light scattering at three separate measurement angles

Determination of zeta potential using patented cmPALS

Molecular mass and refractive index measurements

Litesizer DLS 700

Particle characterization from the nanometer to the micrometer range

High resolution of different size populations via multi-angle particle sizing (MAPS)

Determine the concentration of up to three distinct size classes within one sample

Key Features

Benefit from the Perfect Angle Choice – Whatever the Sample

Litesizer Series of Particle Size Analyzers

Image Credit: Anton Paar GmbH

Ensure great resolution of diverse size populations using multi-angle particle sizing (MAPS)

To optimize parameter settings, select one of three detection angles (side, rear, or forward scattering)

Manually choose the best angle for the dynamic light scattering device or utilize automatic angle selection.

Benefit from the flexible backscattering angle, which is suitable for turbid samples and eliminates numerous scattering events to provide optimal data quality

Rely on the cmPALS Technique for Zeta Potential Measurements

Litesizer Series of Particle Size Analyzers

Image Credit: Anton Paar GmbH

Measure zeta potential using electrophoretic light scattering using the Litesizer DLS 700 and DLS 500

The proprietary cmPALS technology (European Patent 2 735 870) allows for very sensitive readings at low sample concentrations (as low as 0.1 mg/mL)

cmPALS provides quicker measuring times and less sample deterioration

The zeta potential cuvettes include a distinctive Ω-shaped capillary, allowing for extremely reproducible results

Stay Flexible with the Particle Concentration Measurement Mode

Litesizer Series of Particle Size Analyzers

Image Credit: Anton Paar GmbH

With the Litesizer DLS 700, users can perform calibration-free particle concentration measurements of up to three distinct size populations inside one sample.

This mode based on single-angle DLS or multi-angle particle sizing (MAPS) ensures the applicability to monodisperse and polydisperse samples across a large concentration range.

Get Continuous Transmittance Measurements for Sample Monitoring

Litesizer Series of Particle Size Analyzers

Image Credit: Anton Paar GmbH

Obtain continuous transmittance measurements for sample monitoring

Use automated optimization of measurement parameters (e.g., measurement angle, focus position, duration)

Access data on the commencement of sedimentation or aggregation within a series of measurement

Determine Refractive Index with the Same Instrument

Litesizer Series of Particle Size Analyzers

Image Credit: Anton Paar GmbH

Measure the refractive index of the solvent at the precise wavelength and temperature of DLS or ELS measurements (European Patent 3 023 770) using Litesizer DLS 700 and Litesizer DLS 500

Under all experimental circumstances, ensure that particle size and zeta potential results are as accurate as possible.

Use Litesizer DLS 700 and DLS 500 to measure refractive index to within ±0.5% accuracy.

Control the Measurements with Just a Few Clicks

Litesizer Series of Particle Size Analyzers

Image Credit: Anton Paar GmbH

Manage data using Kalliope, the user-friendly particle sizing program

The innovative one-page process allows users to see the input parameters, measurement signals, and outcomes at a glance

Quickly evaluate measurement results with established standard reports and organized result overviews

Explore the data using an analysis function, Excel export, and customized report templates

Comply with 21 CFR Part 11

Technical Specifications

Source: Anton Paar GmbH

Litesizer DLS 700 Litesizer DLS 500 Litesizer DLS 100
Particle size specifications
Measurement principle Dynamic Light Scattering (DLS)
Measuring range 0.3 nm to 10 μm(particle diameter)
Measurement angles 15°, 90°, 175°, Multi-angle particle sizing (MAPS) 15°, 90°, 175° 175°
Min. concentration 0.1 mg/mL (lysozyme)lower than 0.00001 % (0.1 ppm, Latex 100 nm) 0.1 mg/mL (lysozyme)
Max. concentration 50 % w/v (sample-dependent)
Min. sample volume 12 µL
Accuracy Better than +/-2 % on NIST traceable standards
Repeatability Better than +/-2 % on NIST traceable standards
Particle Concentration Specifications
Analysis model Mie Theory - -
Measuring range 108- 1013particles/mL (sample dependent) - -
Size limit 1 µm - -
Measurement angles 15°, 90°, 175°, Multi-angle particle sizing (MAPS) - -
Min. sample volume 12 µL - -
Accuracy +/- 10 % (sample dependent) - -
Repeatability +/- 5 % (sample dependent) - -
Zeta potential specifications
Measuring principle Electrophoretic Light Scattering (ELS) / cmPALS -
Measuring range >= +/-1000 mV -
Mobility range 10-11m²/V.s to 2 x 10-7m²/V.s -
Size range 3.8 nm to 100 µm (diameter) -
Min. sample concentration 0.1 mg/mL (lysozyme) -
Max. sample concentration 70 %w/v (sample-dependent) -
Max. sample conductivity 200 mS/cm -
Min. sample volume 50 µL (sample-viscosity-dependent) -
Accuracy Better than +/-10 % -
Repeatability +/-3 % -
Molecular mass specifications
Measuring principle Static Light Scattering (SLS) -
Measuring range (mass) 300 Da to 20 MDa -
Measuring range (particle size) Up to 40 nm (diameter) -
Measurement angle 90° -
Min. sample concentration 0.1 mg/mL (lysozyme) -
Accuracy +/-10 % -
Repeatability +/-5 % -
Transmittance specifications
Measuring range 0 % to 100 %
Min. sample volume 15 µL
Accuracy Better than +/-1 %
Refractive index specifications
Measuring range 1.28 to 1.50 -
Min. sample volume 1 mL -
Accuracy +/-0.5 % -
General specifications
Light source Semiconductor laser diode / 40 mW, 658 nm
Laser warm-up time 6 min
Temperature control range 0 °C to 90 °C
Ambient operating temperature 10 °C to 35 °C
Humidity Up to 80 % non-condensing
Dimensions (W, D, H) 460 mm, 485 mm, 135 mm
Weight Approx. 18 kg (40 lb) Approx. 16.3 kg (36 lb)
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